Colón sits at the Caribbean mouth of the Panama Canal, and the canal is the reason to be here — many itineraries do a partial transit or visit the Agua Clara locks to watch giant ships climb the staircase of water. Beyond the engineering, the surrounding province offers rainforest and monkey-filled Gatún Lake, the colonial forts of Portobelo, and Embera indigenous villages. The town itself is rough, so an organized tour is the way to go.
Colón town has a rough reputation — book an organized tour rather than wandering on your own. Watching a Panamax ship lift in the Agua Clara locks is the signature experience; the Gatún Lake monkey boat trip pairs perfectly with it.
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